Preheat the oven to 350F. Place a large sheet of foil or parchment on a sheet pan. Lay the salmon filet on top.
Season the op of the salmon filet with salt and pepper, then drizzle with the olive oil.
In a smack bowl, mix together the lime juice, chili powder, ground cumin, and garlic powder. Using a basting brush, brush the mixture all over the top of the salmon.
Place the salmon in the oven and bake for 10-15 minutes. The salmon is cooked when it is opaque and the flesh can be easily flaked with a fork. If white juices are coming to the top, it is overcooking.